Employing an array of media including woodpiles, moving vans, weekend hobbies and plumbing, Daniel Seiple coaxes meaningful experiences out of mundane activities, friendly confrontations and concocted group activity. In 2021, Seiple founded the non-profit Yacht Club für Interkulturelle Forschungs- und Kunstprojekte e.V. to operate and maintain the ship constructed by the Making Waves Boat Making Workshop for Refugees. He is a founding member of the New York-based art collaborative, eteam, and the non-profit collective, KUNSTrePUBLIK e.V., in which he worked as artist, curator, researcher and activist at Skulpturenpark Berlin_Zentrum and in other public art and international contexts.

His work has been included in exhibitions and institutions worldwide including Documenta 15, 5th Berlin Biennial, Musée du Château des ducs de Wurtemberg, France and the Bronx Museum of Art, New York. His projects have received various grants including from the Berlin Senate, German Federal Cultural Foundation and the New York State Council on the Arts.

Seiple is represented by Adamski Gallery in Berlin.